Effect of dextran on the reaction between rheumatoid factor and human gamma globulin.
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منابع مشابه
Interaction of the Rheumatoid Factor with Antigen-antibody Complexes and Aggregated Gamma Globulin
The effect of highly purified rheumatoid factor on the precipitin reactions of various antigen-antibody systems was determined. The amount of nitrogen precipitated was increased over a broad range when the factor was added to ovalbumin, human albumin, or human gamma globulin, and the corresponding rabbit antibodies. In the zone of antigen excess, soluble antigen-antibody complexes were precipit...
متن کاملSpecificity of the Reaction between Rheumatoid Factors and Gamma Globulin
Rheumatoid factors in the sera of patients with rheumatoid arthritis appear to be specifically directed against genetically determined "antigens" in human gamma-globulin. At least eight rheumatoid factors of differing specificity exist; usually several are present in combination in the same serum. The different rheumatoid factors can be readily detected through their pattern of reactivity with ...
متن کاملCharacterization of the "reactant" (gamma Globulin Factor) in the F Ii Precipitin Reaction and the F Ii Tanned Sheep Cell Agglutination Test
The material in gamma globulin ("reactant") which reacts with rheumatoid sera in the F II precipitin and F II tanned sheep cell agglutination tests was concentrated by precipitation with sodium sulfate. The concentrated "reactant" appeared to consist of polydispersed molecular aggregates of gamma globulin with s(20) constants as high as 40, as well as the previously described inhomogeneous aggr...
متن کاملCellular Origin of Rheumatoid Factor
Fluorescein-labelled aggregated human gamma-globulin was found to react in precipitin-type tests with serums of individuals with rheumatoid arthritis. This reagent was also highly reactive and specific for the localization of rheumatoid factor in frozen sections of synovial membranes, lymph nodes, and subcutaneous nodules. In synovial membranes from patients with active rheumatoid arthritis, rh...
متن کاملThe Induction of a Rheumatoid Factor-like Substance in Rabbits
Hyperimmunization of two groups of rabbits with killed Escherichia coli and Bacillus subtilis has resulted in the formation of a serum factor (RFLS) which resembled the human rheumatoid factor. It was a heat-stable protein that migrated electrophoretically in the gamma-beta globulin range and sedimented rapidly with ultracentrifugation. The serologic properties of the RFLS were destroyed by mer...
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ورودعنوان ژورنال:
- Annals of the rheumatic diseases
دوره 32 6 شماره
صفحات -
تاریخ انتشار 1973